Bacterial infections of skin and underlying soft tissue including cellulitis and abscess.
|Preferred antibiotic choice(s)|
|Cloxacillin (PO)||Capsule: 500 mg; 1 g (as sodium salt); Powder for oral liquid: 125 mg (as sodium salt)/5 mL||250 mg 6 hourly||5 days|
|Alternative antibiotic choices:|
|Amoxicillin + clavulanic acid (PO)
Used for patients with animal bitesA.
|Oral liquid: 125 mg amoxicillin + 31.25 mg clavulanic acid/5 mL AND 250 mg amoxicillin + 62.5 mg clavulanic acid/5 mL; Tablet: 500 mg (as trihydrate) + 125 mg (as potassium salt)||500 mg of amoxicillin component 8 hourly||5 days|
|Cefalexin (PO)||Powder for reconstitution with water: 125 mg/5 mL; 250 mg/5 mL (anhydrous); Solid oral dosage form: 250 mg (as monohydrate)||500 mg 6 hourly||5 days|
|In case of confirmed drug allergy or medical contraindication|
|Clindamycin (PO)||Capsule: 150 mg (as hydrochloride); Oral liquid: 75 mg/5 mL (as palmitate)||300 mg 8 hourly||5 days|
A. For patients with suspected animal bite, assess for rabies risk and consider administering a tetanus booster.
Principles of Stewardship:
- Withhold antibiotics for standard, uncomplicated abscess in an otherwise well person if the abscess can be incised and drained.
- If IV antibiotic therapy is clinically indicated, review patient progress at day 3 of treatment to consider switch from IV to oral therapy.